Publications

RG Gaudet, S Zhu, A Halder, BH Kim, CJ Bradfield, S Huang, D Xu, A Mamiñska, TN Nguyen, M Lazarou, E Karatekin, K Gupta and JD MacMicking. A human apolipoprotein L with detergent-like activity kills intracellular pathogens. Science. 373: eabf8113 (2021). PMID: 34437126

• Rethinking Immunology. C Nathan. Science Perspective. 373. 267-277 (2021).

• Human Cells Ward of Bacterial Invaders with a Protein That Behaves Like Soap. Smithsonian Magazine (2021).

• Human Protein Dissolves Bacterial Membranes. The Scientist. (2021).

M Abdel-Nour, LA Carneiro, J Downey, J Tsalikis, A Outlioua, D Prescott, LS Da Costa, ES    Hovingh, A Farahvash, RG Gaudet, R Molinaro, R Dalen C Lau, FC Azimi, NK Escalante, JE Lee, SD Gray-Owen,  JJ Chen, DJ Philpott, D Arnoult, SE Girardin. The heme-regulated inhibitor is a cytosolic sensor of protein misfolding that controls innate immune signaling. Science. 365: eaaw4144 (2019). PDF

 TR O’Meara, K Duah, CX Guo, M Maxson, RG Gaudet, K Koselny, M Wellington, M Powers, J MacAlpine, MJ O’Meara, A Veir, S Grinstein, SM Noble, D Krysan, SD Gray-Owen, LE. Cowen. High-Throughput Screening Identifies Genes Required for Candida albicans Induction of Macrophage Pyroptosis. mBio. 9:4 e01581-18 (2018). PDF                                                                                                                                                                 

 A Gall, RG Gaudet, SD Gray-Owen, and N Salma. TIFA signaling in gastric epithelial cells initiates the cag-T4SS-dependent innate immune response to Helicobacter pylori infection. mBio. 15;8(4). pii: e01168-17. (2017). PDF

RG Gaudet, CX Guo, R Molinaro, JR Rohde, H Kottwitz, AS Dangeard, C Arriemerlou, SE Girardin, and SD Gray-Owen. Innate recognition of intracellular bacterial growth is driven by the TIFA-dependent cytosolic surveillance pathway. Cell Reports. 19: 1418-1430 (2017). PDF

RG Gaudet, CJ Bradfield, and JD MacMicking. Evolution of Cell-Autonomous Effector Mechanisms in Macrophages versus Non-Immune Cells. Microbiology Spectrum. Dec;4(6). doi: 10.1128/microbiolspec.MCHD-0050-2016 (2016). PDF

RG Gaudet and SD Gray-Owen. Heptose sounds the alarm: Innate recognition of a bacterial sugar stimulates immunity. PLoS Pathogens. 12(9): e1005807. doi:10.1371/journal.ppat.1005807. (2016). PDF

RG Gaudet, A Sintsova, CM Buckwalter, N Leung, J Li, A Cox, A Cochrane, J Moffat, and SD Gray-Owen. Cytosolic detection of the bacterial metabolite HBP activates TIFA-dependent innate immunity. Science. 348(6240): 1251-1255 (2015). PDF

• Microbial metabolite triggers antimicrobial defense. Science Perspective. (2015).

• New PAMP discovered. Nature Reviews Immunology Research Highlight. (2015).

RM Malott, B Keller, RG Gaudet, S McCaw, C Lai, W Belaire, J Hobbs, F St. Michael, A Cox, T Moraes, and SD Gray-Owen. Neisseria gonorrhoeae-derived heptose elicits an innate immune response and drives HIV-1 expression. PNAS. 110(25): 10234–10239 (2013). PDF

RG Gaudet, F Breden, F Plummer and JD Berry. Molecular characterization of the cervical and systemic B-cell repertoire: Unique, yet overlapping immune compartments of an HIV-1 resistant individual. Mabs. 3(2): 1-11 (2011). PDF

JD Berry and RG Gaudet. Antibodies in infectious diseases, polyclonals, monoclonals and niche biotechnology. New Biotechnology. 28(5):489-501 (2011). PDF